基于粒计算的商业数据流概念漂移特征选择

商业数据流具有动态性、漂移性等特性,概念漂移特征选择是数据流挖掘的重要工作之一.本文从数据流的特点和概念漂移特性出发,提出了数据流的概念形式化分析流程和基于粒计算构建数据流的概念形式化描述模型;商业数据流的概念漂移实际上取决于其概念外延的变化,文中使用包括外延偶合度和内涵偶合度在内的概念偶合度来描述概念间的相似性;经过粒化的数据流由概念格来表示,进而通过概念格对的松弛偶合度来分析数据流特征;结合概念偶合分析和数据流变化特征,阐述了一种基于数据流概念格对的松弛匹配偶合度算法,并据此分析概念格对来选择数据流的漂移特征.通过实例验证、评价了特征选择,证明其有效性.     

天津海河中游区域开发环境容量与环境影响分析

环境容量分析是区域环境规划与评价的基础.在对天津海河中游区域环境容量分析的基础上对开发活动将造成的环境影响进行了分析.分析结果表明,天津海河中游区域已经没有水环境容量,区域开发活动将进一步加剧天津海河中游区域水资源供应危机,开发活动排放的化学需氧量、氨氮和工业废气将导致水环境、大气环境进一步恶化.根据优化模拟结果,提出...     

基于语义维度的人脸表情生成

为实现有丰富表现力的人脸表情生成,提出一种基于语义维度的人脸表情生成方法。首先定义了与人类情感、态度、意图等情态信息相关的7个语义维度,对表情图像进行语义维度标注;进而对面部器官的典型状态进行量化,定义并提取人脸局部状态参数。分别采用线性回归和人工神经网络方法,建立了语义维度与人脸局部状态参数的映射模型。实验结果表明:基于语义维度的方法能够生成与文本语义相贴切的人脸表情,神经网络模型在参数预测精度和主观感知评价方面均优于线性模型。     

手指口述安全管理方法的探讨

大多数煤矿生产事故是由于人的不安全行为造成的,通过执行"手指口述"方法,可以使员工对自己的操作行为以及作业环境的安全状态进行确认,通过提高员工自主管理和互助保安意识,保证操作过程安全可靠,消除生产事故隐患,从而可以提高安全管理水平,促进矿井安全生产.     

The ribosome uses two active mechanisms to unwind messenger RNA during translation

The ribosome translates the genetic information encoded in messenger RNA into protein. Folded structures in the coding region of an mRNA represent a kinetic barrier that lowers the peptide elongation rate, as the ribosome must disrupt structures it encounters in the mRNA at its entry site to allow translocation to the next codon. Such structures are exploited by the cell to create diverse strategies for translation regulation, such as programmed frameshifting, the modulation of protein expression levels, ribosome localization and co-translational protein folding. Although strand separation activity is inherent to the ribosome, requiring no exogenous helicases, its mechanism is still unknown. Here, using a single-molecule optical tweezers assay on mRNA hairpins, we find that the translation rate of identical codons at the decoding centre is greatly influenced by the GC content of folded structures at the mRNA entry site. Furthermore, force applied to the ends of the hairpin to favour its unfolding significantly speeds translation. Quantitative analysis of the force dependence of its helicase activity reveals that the ribosome, unlike previously studied helicases, uses two distinct active mechanisms to unwind mRNA structure: it destabilizes the helical junction at the mRNA entry site by biasing its thermal fluctuations towards the open state, increasing the probability of the ribosome translocating unhindered; and it mechanically pulls apart the mRNA single strands of the closed junction during the conformational changes that accompany ribosome translocation. The second of these mechanisms ensures a minimal basal rate of translation in the cell; specialized, mechanically stable structures are required to stall the ribosome temporarily. Our results establish a quantitative mechanical basis for understanding the mechanism of regulation of the elongation rate of translation by structured mRNAs.     

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells

Although immune mechanisms can suppress tumour growth, tumours establish potent, overlapping mechanisms that mediate immune evasion. Emerging evidence suggests a link between angiogenesis and the tolerance of tumours to immune mechanisms. Hypoxia, a condition that is known to drive angiogenesis in tumours, results in the release of damage-associated pattern molecules, which can trigger the rejection of tumours by the immune system. Thus, the counter-activation of tolerance mechanisms at the site of tumour hypoxia would be a crucial condition for maintaining the immunological escape of tumours. However, a direct link between tumour hypoxia and tolerance through the recruitment of regulatory cells has not been established. We proposed that tumour hypoxia induces the expression of chemotactic factors that promote tolerance. Here we show that tumour hypoxia promotes the recruitment of regulatory T (T(reg)) cells through induction of expression of the chemokine CC-chemokine ligand 28 (CCL28), which, in turn, promotes tumour tolerance and angiogenesis. Thus, peripheral immune tolerance and angiogenesis programs are closely connected and cooperate to sustain tumour growth.     

县域经济发展中的居民消费研究

居民消费在县域经济发展中处于怎样的情况,文章就平鲁区居民消费的基本情况进行了分析.     

Fermat小定理的推广及其应用

利用映射的不动点以及不动点阶的思想将整数环Z上的Fermat小定理推广到一般集合S上，并运用该推广讨论了Dirichlet定理的一种特殊情形：只要给定正整数m≥3，那么算术数列1＋lm（l=0，1，2，…）中一定存在无穷多个素数．     

经济发展与制度创新浅析

文章分析制度创新在经济发展过程中的重要性，指出有好的制度，才能保证有良好的经济运行秩序和高效办事程序。     

甘肃徽县金滩子金矿地质特征与找矿标志

金滩子金矿位于南秦岭复杂褶皱带上。从区域地质背景、含矿建造、中酸性岩体以及成矿构造等几个方面讨论了金滩子金矿的成矿条件,通过分析认为,该矿床为较典型的中低温热液破碎带蚀变岩型矿床,中酸性岩体为金成矿提供了丰富的物质来源,金矿严格受中酸性岩体和断裂构造控制。